Clptml1 cancer scholar

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August undefined, 2024

WebJul 9, 2014 · Introduction. Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009 .Esophageal cancer is very aggressive and is associated with a poor prognosis .Esophageal squamous cell carcinoma (ESCC) accounts for more than 90 percent of esophageal cancers … WebSep 29, 2024 · CLPTM1L is the homologous protein gene of CLPTM1. CLPTM1 was reported for the first time in a cleft lip and palate family with a translocation breakpoint …

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WebJan 12, 2016 · A recent meta-analysis of 85 studies including over 490,000 subjects that evaluated 67 TERT/CLPTM1L locus polymorphisms and 24 tumor types identified 11 SNPs with strong cumulative evidence for an association with at least one cancer type. rs31489 was one of these SNPs and was found to have strong cumulative evidence for … WebMar 29, 2024 · Overexpression of Cleft Lip and Palate Transmembrane 1-Like (Clptm1L) confers cancer cell survival through the endoplasmic reticulum (ER) stress survival … snickers powder

The TERT-CLPTM1L lung cancer susceptibility variant associates …

WebNational Center for Biotechnology Information WebJun 23, 2024 · Abstract. Lung cancer is a common cancer in human and has presented significant genetic predisposition. Previous genome-wide association study observed that rs401681 within CLPTM1L (CLPTM1 like) was significantly associated with lung cancer. By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby … WebFeb 28, 2014 · To date, many studies have indicated that CLPTM1L and TERT genes were candidate susceptible genes for many diseases, in which SNPs and CNV were reported … roady pessac

CRR9/CLPTM1L regulates cell survival signaling and is required for …

Targeted biologic inhibition of both tumor cell-intrinsic and

Web10). The variant was also significantly associated with triple-negative (ER-negative, progesterone receptor (PR)-negative and human epidermal growth factor-2 (HER2)-negative) breast cancer (OR = 1.25, P = 1.1 × 10 -9), particularly in younger women (<50 years of age) (OR = 1.48, P = 1.9 × 10 -9).Our results identify a genetic locus associated … WebFeb 6, 2016 · CLPTM1L encodes a protein linked to cisplatin-resistant ovarian tumor cell lines and is expressed in cells of various tumor types, including skin, lung, breast, … snickers priceWebDec 26, 2012 · CLPTM1L is believed to be associated with lung cancer. However, there is little information regarding its expression and function. Here using immunohistochemistry, we found that CLPTM1L expression … snickers protein bar walmart

"WebFeb 6, 2016 · Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study to examine the potential association of CLPTM1L single nucleotide polymorphisms (SNPs) with lung cancer in a Chinese … " - Clptml1 cancer scholar

Clptml1 cancer scholar

Functional Characterization of CLPTM1L as a Lung Cancer …

WebDec 16, 2016 · Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer … WebMar 2, 2024 · Next, we evaluated the levels of CLPTM1L and cancer stem cell markers in a panel of high-grade serous ovarian carcinoma ... CAS PubMed Google Scholar Mobuchon, L. et al. A GWAS in uveal melanoma ...

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WebAssociations Between TERT-CLPTM1L Variants and Risk of Cancer and Non-Cancer Diseases. We conducted meta-analyses to assess relationships of 23 variants in TERT … WebJun 4, 2012 · Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most …

WebNov 1, 2024 · Cancer susceptibility of the rs401681 polymorphism, located in the TERT-CLPTM1L locus, has been studied in many cancers. We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer. The relationship between rs401681 variants and telomere length was analyzed in 134 non-small cell lung cancers … WebMay 15, 2014 · Our results suggest that CLPTM1L functions as a growth-promoting gene in the pancreas and that overexpression may lead to an abrogation of normal cytokinesis, …

WebMay 22, 2009 · Introduction. Lung cancer is the most common cancer worldwide, both in terms of incidence and mortality. Smoking and occupational–environmental exposure are well established to be the major etiological risk factors for lung cancer risk ( 1).The carcinogenic polycyclic aromatic hydrocarbons (PAHs) and the tobacco-specific … WebSep 29, 2024 · This study aimed to explore the function of CLPTM1L in oral squamous cell carcinoma and mechanism of tumorigenesis. The expression of CLPTM1L was detected …

WebCLPTM1L is believed to be associated with lung cancer. However, there is little information regarding its expression and function. Here using immunohistochemistry, we found that …

WebJul 7, 2010 · Abstract. Background: A recent study reported genetic variants in the TERT-CLPTM1L locus that were associated with mean telomere length, and with risk of multiple cancers.Methods: We evaluated the association between single nucleotide polymorphism (SNP) rs401681 (C > T) and mean telomere length, using quantitative real-time PCR, in … roady rang du fliersWebApr 8, 2024 · A biomimetic nanoplatform combining PPE and elevated histone H1 release induced by porphyrin nuclear localisation signal peptide is developed and demonstrated its efficacy in preclinical cancer models. Precise discrimination and eradication of cancer cells by immune cells independent of antigen recognition is promising for solid tumor … snickers protein bars nzWebSep 29, 2024 · Multiple genome-wide association studies (GWAS) have demonstrated that the TERT-CLPTM1L genetic variation at 5p15.33 is correlated with the risk of various malignant tumors, such as lung cancer, cervical cancer, pancreatic cancer, bladder cancer, glioma, prostate cancer, basal cell carcinoma and melanoma, and oral cancer … roady oloronWebNov 30, 2012 · A TERT-CLPTM1L SNP, rs401681 (C>T, located in the intron 13 of CLPTM1L and 27 kb from the TERT gene), is one of the most extensively studied SNPs. It has been reported to be associated with an increased risk of lung cancer through genome-wide association studies (GWAS) , , , , . However, the reported genetic effects varied … snickers protein bar boxWebFeb 1, 2007 · Figure 1. Transductional targeting for increasing gene transfer into prostate cancer cells. A-D, cell lines were infected with replicationdeficient luciferase expressing Ad5luc1, and isogenic capsidmodified viruses Ad5/3luc1 and Ad5lucRGD. Ad5luc1 has a wildtype Ad5 capsid, whereas Ad5/ 3luc1 and Ad5lucRGD feature capsids modified with … roady roady road trip ddlc roady revision tarifWebAug 15, 2012 · Single-nucleotide polymorphism of CLPTM1L-rs401681(C > T) at the 5p15.33 locus is significantly associated with cancer risk as reported in genome-wide association studies, but the reported studies for non-melanoma skin cancer (NMSC) are inconclusive. To assess the association between rs401681[C] allele and NMSC risk, we … roady riom 63200