WebJan 21, 2024 · The production of CSF1 in sensory neurons was shown to be essential for pain related behavior in mice following a nerve injury as mechanical allodynia could be ameliorated by either knocking out Csf1 or blocking the CSF1 receptor (Guan et al., 2016, Okubo et al., 2016, Lee et al., 2024, Zhou et al., 2024). WebSep 7, 2024 · CSF1 drives pain in arthritis. Colony-stimulating factor 1 (CSF1; also known as M-CSF) is involved in the development of cells of the monocyte–macrophage lineage, …
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WebOct 23, 2024 · These data are consistent with previous work suggesting that CSF1-CSF1R signaling represents a key response to injury both in the context of demyelination 33 as well as neuropathic pain 51,52. One clear mechanism in this injury response is the upregulation of astrocytic CSF1 expression which subsequently functions in a non-cell autonomous ... WebJan 12, 2016 · Hypersensitivity to pain was reduced in mice with Csf1 deletion, and CSF-1 injected into the spinal canal restored pain hypersensitivity. Nerve injury and spinal … flynn optometry hours
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WebNov 1, 2024 · Peripheral pain signals are transmitted to the SDH via the dorsal root ganglion, which continuously activates neurons in the SDH, promoting NP development [5]. A clinical study showed that intrathecal injection of opioid analgesics exerted analgesic effects by directly acting on the SDH and nerve roots [6]. WebJul 9, 2024 · It is well established that nerve injury causes DRG neuronal damage and the expression of CSF1 in injured DRG neurons, and CSF1 further induces microglial activation in the spinal cord that plays an important role in the pathogenesis of neuropathic pain. 24–27 To test whether GPR151 in DRG neurons is involved in microglial activation, we ... WebApr 12, 2024 · CSF1, IL-6, and STAT1, which are related to the pro-inflammatory mechanism, were significantly upregulated in the OGD group compared to the non-OGD group. ... Pain Res. Manag. 2024, 8286190 (2024 ... flynn ottoman cr laine