Cytoplasmic polyadenylation element
WebThe cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific mRNA binding proteins that control translation in development, health, and disease. WebCytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB — a highly conserved, sequence-specific RNA-binding protein that binds to the cytoplasmic...
Cytoplasmic polyadenylation element
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WebCytoplasmic polyadenylation element-binding protein 1 Short names CPE-BP1; CPE-binding protein 1; mCPEB; mCPEB-1 Gene names Name Cpeb1 Synonyms Cpeb Organism names Organism Mus musculus (Mouse) Taxonomic … WebJan 1, 2024 · Cytoplasmic Maturation 197 Components of the Translational Program in Oocytes 197 Poly (A) Tail Length Determines the Rate of Translation of Maternal mRNAs 199 Additional Posttranscriptional mRNA Modifications 199 RNA-Binding Proteins in the Oocyte 200 Biological Significance of the Translation Program in Oocytes 204
WebSep 12, 2024 · Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated region (UTR) of specific mRNAs and assemble an activator complex promoting the translation of target mRNAs through cytoplasmic polyadenylation. Results WebThe cytoplasmic polyadenylation element (CPE) is a nucleotide sequence within the 3′ UTR of mRNAs which binds to the CPE-binding protein (CPEB). From: Progress in …
WebNov 24, 2015 · The cytoplasmic polyadenylation (CP) element, Pumilio binding element, and hexanucleotide polyadenylation signal are among the best understood motifs involved in CP, and translational regulation of … WebIn addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, …
WebNov 25, 2004 · Cytoplasmic polyadenylation depends on phosphorylation of CPEB, a protein that is bound to specific cytoplasmic polyadenylation elements (CPEs) in the 3' ends of transcripts regulated in this manner. In Xenopus , phosphorylation is mediated by the protein kinases Eg2 (known as Aurora A in the mouse) and Cdc2.
WebFeb 25, 2016 · Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of polyadenylation factors interacting with 3'UTRs of mRNA and thereby regulating gene expression. Various functions of CPEBs in development, synaptic plasticity, and cellular senescence have been reported. importance of rbacWebCytoplasmic polyadenylation, which is one mechanism of controlling translation, is driven by CPEB — a highly conserved, sequence-specific … literary devices in roman feverWebResults: We show that cytoplasmic polyadenylation element-binding protein 4 (CPEB4), which controls the translation of specific mRNAs by modulating their poly (A) tails, is highly expressed in visceral fat of obese but not lean humans and rodents (mice and rats), where it orchestrates an essential post-transcriptional reprogramming for … importance of reaching out to othersWebSequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR ( By similarity ). By … importance of rcepWebJun 14, 2013 · The cytoplasmic polyadenylation element (CPE) recruits its binding protein CPEB1. 96 This binding can be stabilized, especially on noncanonical CPEs, by the recruitment of Pumilio (PUM2) to the Pumilio binding element (PBE) and protein–protein interactions between CPEB1 and PUM2. 99, 121 CPEB1 in turn interacts with the … importance of reading 20 minutes a dayWebAug 15, 2024 · The cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates the translation of several mRNAs important for long-term synaptic plasticity in the hippocampus. In previous studies, we found that the oligomerization and activity of CPEB3 are controlled by small ubiquitin-like modifier (SUMO)ylation. In the basal state, CPEB3 is ... literary devices in song lyricsWebThe cytoplasmic polyadenylation element is a sequence element found in the 3' untranslated region of messenger RNA. While several sequence elements are known to … importance of rbi