WebJul 16, 2024 · After treatment by GSH, an obvious N1s peak appears in Cu-MOF due to the residues of GSH . Furthermore, after treatment of GSH, the XPS analysis of Cu(I)-MOF only shows Cu(I) (932.7, 952.4 eV) peaks , also confirming the reduction of Cu-MOF by GSH. WebThe generation of reactive oxygen species (ROS) is often limited by the overexpression of glutathione (GSH) in the tumor microenvironment (TME) and the penetration depth of visible light.
GSH-Responsive Metal-Organic Framework for …
WebFeb 24, 2024 · In this work, a metal–organic framework (MOF)-based cascade catalytic glutathione-depleting system named MnFe 2 O 4 @MIL/Au&GOx (MMAG) was constructed. The MMAG cascade-catalyzed glucose to provide H + and produces a large amount of toxic reactive oxygen species. In addition, MMAG consumed GSH, which can result in … WebApr 23, 2024 · Notably, based on the direct adsorption of GSH, MOF-2 showed a comparable effect with the commercial antitumor drug camptothecin in a mouse breast cancer model. This work provides strong evidence for MOF-2 as a promising new PDT candidate and anticancer drug. Keywords: antitumor agents; glutathione; metal-organic … tanista.pgw.jp/bsp_royaldress/psw.htm
Glutathione responsive nitric oxide release for
WebGSH. Abbreviation for glutathione. Farlex Partner Medical Dictionary © Farlex 2012. WebFeb 16, 2024 · This MOF-2 is readily taken up by breast cancer cells, and high levels of ROS are generated under light irradiation. Meanwhile, intracellular GSH is considerably decreased owing to absorption on MOF-2; this synergistically increases ROS concentration and accelerates apoptosis, thereby enhancing the effect of PDT. WebMar 2, 2024 · In this work, a metal-organic framework (MOF)-based cascade catalytic glutathione-depleting system named MnFe 2 O 4 @MIL/Au&GOx (MMAG) was constructed. The MMAG cascade-catalyzed glucose to provide H + and produces a large amount of toxic reactive oxygen species. In addition, MMAG consumed GSH, which can result in … tanist group limited